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There are basically two major areas of research in the Biomedical Sciences: Blood flow and blood vessels and Cartilage mechanics:

1)   Research in Biomedical Sciences >

    a)   Blood Flow and Blood Vessels >

              Software Development >

              Laboratory Investigations >

    b)   Cartilage Mechanics >

2)   General Field Problems >

3)   Examples >

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MedCFD: The First User-Friendly CFD program to Simulate blood flow through an Aneurysm

1) Research in the Biomedical Sciences


a) Blood Flow and Blood Vessels

Software Development. Our main activity is to develop tools for the modern hemodynamicist and cardiovascular surgeon to study and interpret the constantly increasing amount of information being produced by non-invasive imaging equipment.

In addition, this project assumes high-quality quick-display visualization for both the 3D geometrical model of the vessel region of interest and the results of the numerical simulations, i.e. the fields of the flow variables (flow velocity, fluid particle trajectories, pressure, shear stress distribution at the blood-wall interface).

Construction of Finite Element meshes from a 3D medical imaging data set of a confined region of the cardio-vascular system is one of the very important step in our work.

An important outcome of the project will be developing a software system that is able to process and visualize 3D medical data, to reconstruct the geometry of arteries of specific patients, to simulate blood flow in them and to develop the software system for surgical planning.

We claim that the generation of patient-specific finite-element models is technically feasible and desirable. We offer specific software development for improving CT Scan or/and UltraSound device in order to make the future clinical-diagnostics software system.

Laboratory Investigations. Determination of mechanical and functional characteristics of tissue (including blood vessels) by in vitro-and in-vivo laboratory investigations. Measurements by the stretch system for uniaxial and biaxial loading conditions give results that lead to better understanding of various phenomena. These results are also used to establish material models in the computer simulations to realistically predict the response of tissue.

b) Cartilage Mechanics

The developed computational tools for modeling of cartilage deformations and muscle models provides a basis to further develop software for studying spine problems, with a software that directly connects measurements by common techniques in medicine and computer simulations. The simulations give response of the spine sections subjected to various loading conditions. The user-friendly specific software will provide information to surgeon to plan the intervention and predict the outcome.

2) General Field Problems

Software development for solving problems in mechanics of solids and fluids, mass and heat transfer, including coupling between several physical fields, as solid-fluid interaction and mass and heat transfer. This type of problems are general structural problems in engineering and in medicine, as modeling of alveolated flow with large deformations of alveolas and particle tracking and deposition simulations, or modeling of urinary bladder deformations. Developments also assume creation of specific user-friendly software for easy computer simulations, display of results of the simulations, direct connection to other measurements as ultra-sound recording, and interactive work in measurements and simulations.

3) Examples:



Development of Computational Methods and Software for Blood Vessels Modeling Based on Experimental and Clinical Research


Estimation of Risk Groups with Respect to the Spinal Motion Segment  (SMS) Disorder by Use of Numerical Simulation

Interactive Medical Software - The First User-Friendly CFD program to Simulate Blood Flow through an Aneurysm!


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